Local pride will be at stake on Merseyside this Saturday, as Liverpool host Everton live on PremPlus, while leaders Manchester United will face a test of their mettle on Sunday when they visit Tottenham - live on Sky Sports 1.
Chelsea are giving chase to Manchester United and they travel across London to face struggling Charlton, while Arsenal visit Middlesbrough at Saturday teatime - live on PremPlus.
Two of the most active teams in the January transfer window, Aston Villa and West Ham, lock horns at Villa Park, while bottom club Watford entertain Bolton at Vicarage Road.
Wigan have suffered an alarming dip in form in the last couple of months and manager Paul Jewell will be desperate for his side to arrest their slide against Portsmouth on Saturday.
Fulham host a Newcastle side who are unbeaten in four games in the Premiership, while Blackburn will be looking to bounce back from their defeat against Chelsea when they entertain Sheffield United and Reading travel to Manchester City.
Liverpool v Everton preview - live on PremPlus
The Reds have lost just one of their last 10 Premiership Merseyside derbies at Anfield. The winning side has scored three goals in each of the last three meetings between the two sides.
Aston Villa v West Ham preview
Nine of the last 13 Premiership meetings between the two sides have ended in draws. Marlon Harewood has bagged four goals in his last three league meetings with Villa.
Blackburn v Sheffield United preview
The Blades have never won against Blackburn in the Premiership. Rovers have kept just two clean sheets in their 12 home Premiership games this season.
Charlton v Chelsea preview
Charlton have accrued just one point from their seven capital Premiership derbies this season, while The Blues have managed 11 points from their six London clashes.
Fulham v Newcastle preview
The Cottagers have lost just one of their last five meetings with Newcastle. Four of the last seven meetings between the two sides have been away wins.
Manchester City v Reading preview
City have failed to find the net in four of the last five meetings between the two clubs. Reading have scored one goal in each of their last three clashes with City.
Watford v Bolton preview
In their 12 visits to Watford in all competitions Bolton have only managed one victory with that win coming in the FA Cup last January (3-0).
Wigan v Portsmouth preview
The Latics have conceded 18 goals in their last six league games. Pompey have gone five games without a win.
Middlesbrough v Arsenal preview - live on PremPlus
Boro have kept just two clean sheets in their 23 Premiership clashes with Arsenal. Thierry Henry has scored 11 goals in 13 appearances v Boro in the Premiership.
Sunday
Tottenham v Manchester United preview
Spurs are without a win in the last 11 premiership meetings with United. There has only been one goalless draw in the last 25 meetings between the two sides in all competitions.