Manchester United will be aiming to ring in the New Year in style by extending their lead at the top of the table when they visit Newcastle.
Sir Alex Ferguson's men have won all three of their games over the festive period and they will be looking for maximum spoils from their trip to Tyneside, live on Sky Sports 1.
Liverpool and Bolton meet in the first Premiership game of 2007 at Anfield, live on Sky Sports 1.
Bolton are currently sitting in third spot, two points above fourth placed Liverpool as both sides fight to finish in the top four.
Portsmouth and Tottenham will both be looking to get back to winning ways at Fratton Park live on PremPlus.
Sheffield United will be hoping to build on their famous win over Arsenal when they travel to fellow strugglers Middlesbrough.
West Ham make the trip to Reading in desperate need of the points after losing their last two games.
Fulham entertain bottom of the table Watford at Craven Cottage in a battle of two of the youngest managers in the Premiership.
Manchester City play host to Everton at Eastlands aiming to continue their recent improvement in form.
Wigan and Blackburn do battle in a Lancashire derby at the JJB Stadium with the home side looking to climb away from trouble.
Fulham v Watford 3pm
This will be only the two sides' second ever meeting in the Premiership.
Liverpool v Bolton 12.45pm - live on Sky Sports 1
The Trotters have never won a New Year's Day game in the Premiership, drawing three and losing two.
Man City v Everton 3pm
City have won four of their last five home Premiership encounters with Everton, scoring fifteen goals in total in those games.
Middlesbrough v Sheff Utd 3pm
Boro have failed to win any of their last six meetings with the Blades (in all competitions).
Newcastle v Man Utd 5.15pm - live on Sky Sports 1
Newcastle have lost their last four home Premiership matches against Manchester United.
Portsmouth v Tottenham 3pm
Spurs have won their last four meetings with Pompey, hitting 10 goals in the process.
Reading v West Ham 3pm
The teams have met on only six occasions in their history, with Reading winning three, West Ham winning two and one game ending in a draw.
Wigan v Blackburn 3pm
Wigan have failed to secure a victory in any of their seven meetings with Blackburn in all competitions.